ABSTRACT
<p><b>OBJECTIVE</b>To observe the efficacy of the treatment of refractory wound by VSD combined with platelet-rich plasma.</p><p><b>METHODS</b>From April 2010 to June 2012,15 patients with refractory wound were treated including 11 males and 4 females with an average age of 35.2 years old ranging from 18 to 45 years old. The formation time of wound was from 6 to 24 months, which was unhealed after long-term medication or repeated treatment. The VSD combined with autologous platelet-rich plasma was applied to treat the wound. The wound healing was an indicator and treatment and clinical features were summarized.</p><p><b>RESULTS</b>All the patients were followed up for 3 to 8 months (means 5 months). The wound of all patients were healed without recurrence.</p><p><b>CONCLUSION</b>The curative effect of VSD combined with platelet rich plasma for treatment of refractory wounds is obvious. It could reduce the treatment course and the treatment cost.</p>